Orencia: Try Again in Lupus? (CME/CE)
(MedPage Today) -- Benefits seen for articular symptoms
Discussion Sjögren Syndrome (SS) is named for Swedish ophthalmologist Henrik Sjögren who published a case series in 1933 describing patients with dry eyes and arthritis. SS is a “chronic autoimmune inflammatory exocrinopathy” that is characterized by lymphocytic infiltration of the lacrimal and salivary glands and has various degrees of systematic involvement. Keratoconjunctivitis sicca and xerostomia are the main clinical symptoms. Sicca is a Latin word meaning dry. Dryness of the eyes and mouth without evidence of autoimmune disease is called Sicca syndrome or Sicca complex. SS can be primary or se...
We report the case of a 53‐year‐old female with an erythematous, papular eruption occurring in association with Hodgkin lymphoma. Histopathological evaluation of the rash confirmed PNGD. To the best of our knowledge, this is the first case of PNGD occurring in association with Hodgkin lymphoma. Although extremely rare, underlying malignancy should be considered in patients with PNGD, particularly in individuals with constitutional symptoms and the absence of an obvious inflammatory etiology.
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Publication date: April 2018 Source:Research in Veterinary Science, Volume 117 Author(s): Federica Di Profio, Irene Melegari, Vittorio Sarchese, Serena Robetto, Sandra Bermudez Sanchez, Emanuele Carella, Riccardo Orusa, Patrizia Cavadini, Antonio Lavazza, Fulvio Marsilio, Vito Martella, Barbara Di Martino European brown hare syndrome virus (EBHSV) was detected in a faecal swab collected from a wolf carcass in Northern Italy. The full-length genome of the EBHSV WOLF/17/2016/ITA strain was determined. In the VP60 capsid gene, the wolf strain displayed the highest genetic identity (99.2–99.1% nucleotide and 99.6–...
In this study, we compared the characteristics and bone histomorphometric findings between subtrochanteric and diaphyseal sites in patients with BP-associated AFFs. Nine women with BP-associated AFFs were recruited, including 3 with systemic lupus erythematosus, 2 with rheumatoid arthritis, 2 with primary osteoporosis, 1 with polymyalgia rheumatica, and 1 with sarcoidosis. Patients were divided into the subtrochanteric group (n = 5; average age, 52 years; BP treatment, 5.9 years) and the diaphyseal group (n = 4; average age, 77 years; BP treatment, 2.6 years). Compared with the diaphyseal group, the subtrochanteric group h...
ConclusionGiven the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.
ConclusionIn SLE patients with active disease, both the SF‐36 and LupusQoL are sensitive to change, reflecting both improvement and worsening. More importantly, the LupusQoL SLE‐specific domains (planning, burden to others, body image, and intimate relationships) were largely responsive to change.
A 55-year-old Ghanaian man was admitted to our service with 4 days of acute, progressive dyspnea. He developed orthopnea the night prior to his admission. Review of systems revealed progressive asthenia, anorexia and low grade fever for the past few months, with an unintentional weight loss of approximately 40 lbs. No other symptoms were elicited.
Authors: Thomas C, Robinson JA Abstract Preview The great majority of patients with systemic lupus erythematosus have positive antinuclear antibody (ANA) test results. However, other rheumatic and nonrheumatic diseases, certain drugs, infections, and pregnancy can also cause positive results. Thus, a negative ANA test is sometimes more helpful than a positive one when evaluating patients who do not clearly meet diagnostic criteria for rheumatic disease. The authors summarize appropriate use of the ANA test and how to interpret results. PMID: 29206619 [PubMed]
This article is protected by copyright. All rights reserved. PMID: 29215161 [PubMed - as supplied by publisher]