Dose-Response Modeling of the Visual Pathway Tolerance to Single-Fraction and Hypofractionated Stereotactic Radiosurgery

Patients with tumors adjacent to the optic nerves and chiasm are frequently not candidates for single-fraction stereotactic radiosurgery (SRS) due to concern for radiation-induced optic neuropathy. However, these patients have been successfully treated with hypofractionated SRS over 2-5 days, though dose constraints have not yet been well defined. We reviewed the literature on optic tolerance to radiation and constructed a dose-response model for visual pathway tolerance to SRS delivered in 1-5 fractions.

Source: Seminars in Radiation Oncology - March 20, 2016 Category: Cancer & Oncology Authors: Susan M. Hiniker, Leslie A. Modlin, Clara Y. Choi, Banu Atalar, Kira Seiger, Michael S. Binkley, Jeremy P. Harris, Yaping Joyce Liao, Nancy Fischbein, Lei Wang, Anthony Ho, Anthony Lo, Steven D. Chang, Griffith R. Harsh, Iris C. Gibbs, Steven L. Hancock, Source Type: research