A New Triterpenoid from the Aerial Parts of Agrimonia pilosa.

A New Triterpenoid from the Aerial Parts of Agrimonia pilosa.
Nat Prod Commun. 2015 Dec;10(12):2041-4
Authors: Ma JH, Jiang QH, Chen Y, Nie XF, Yao T, Ding LQ, Zhao F, Chen LX, Feng Q
Abstract
(1S,3R,17R,18R,19R,20R,22R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2-6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compound 1 was deduced by circular dichroism (CD). Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia. Compounds 2-6 were tested for anti-inflammatory activities against RAW 264.7 macrophages. A plausible biosynthetic pathway for compound 1 in A. pilosa was also proposed.
PMID: 26882660 [PubMed - in process]

Source: Natural Product Communications - February 19, 2016 Category: Biochemistry Tags: Nat Prod Commun Source Type: research