Retinal Detachment and Symptomatic Hypercalcemia in a Patient with Sarcoidosis: Unusual Presentation of a Granulomatous Disease.

We describe herein a unique presentation of sarcoidosis with retinal detachment and symptomatic hypercalcemia as its first manifestation. Prompt therapy with steroids is indicated in these cases, and an immediate ophthalmology referral cannot be overemphasized. PMID: 26882785 [PubMed - in process]
Source: Connecticut Medicine - Category: Journals (General) Authors: Tags: Conn Med Source Type: research

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Although it is the general consensus that sarcoidosis patients who present with sarcoidosis-related symptoms have a worse outcome than patients whose disease is detected incidentally without symptoms, this premise has not been rigorously examined.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Radiology,Volume 291, Issue 1, Page 261-266, April 2019.
Source: Radiology - Category: Radiology Authors: Source Type: research
[Enlarged mediastinal lymph nodes of a patient with malignant melanoma stage IV under pembrolizumab treatment]. Hautarzt. 2019 Mar 18;: Authors: Nikolakis G, Brunner M, Boye H, Arndt N, Altenburg A, Vaiopoulos A, Zouboulis CC Abstract A 40-year-old patient with malignant melanoma pT4bN0M1a stage IV (AJCC classification 2017) was treated with the PD-1/PD-L1 antibody pembrolizumab. Three months after treatment initiation the patient developed enlarged mediastinal lymph nodes despite the partial response of the cutaneous metastases. An elective lymph node extirpation was performed...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
AbstractSarcoidosis is an inflammatory disease defined by the presence of non-caseating granulomas. It can affect a number of organ systems, most commonly the lungs, lymph nodes, and skin. Cutaneous manifestations of sarcoidosis can impose a significant detriment to patients ’ quality of life. The accepted first-line therapy for cutaneous sarcoidosis consists of intralesional and oral corticosteroids, but these can fail in the face of resistant disease and corticosteroid-induced adverse effects. Second-line agents include tetracyclines, hydroxychloroquine, and methotr exate. Biologics are an emerging treatment option...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
AbstractPurposeReduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status.MethodsPhysical activity was assessed over one week in 15 patients with pulmonary sarcoidosis and 14 age-matched healthy controls with a tri-axial accelerometer (ActivPal ™) and the International Physical Activity Questionnaire (IPAQ). Al...
Source: Lung - Category: Respiratory Medicine Source Type: research
ConclusionsThe algorithm involving CHITO, hs-CRP, and ACE could be a suitable strategy for differentiation between sarcoidosis activity/remission status.
Source: Lung - Category: Respiratory Medicine Source Type: research
ConclusionEPS may help with risk stratification in patients with CS and abnormal imaging, especially those without conventional indications for ICD placement. Among patients with LVEF>35% and no history of prior VA, a negative EPS has good positive and negative predictive value for future VA events.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Authors: Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ Abstract Multimodality cardiovascular imaging is routinely used to assess cardiac function, structure, and physiological parameters to facilitate the diagnosis, characterization, and phenotyping of numerous cardiovascular diseases (CVD), as well as allows for risk stratification and guidance in medical therapy decision-making. Although useful, these imaging strategies are unable to assess the underlying cellular and molecular processes that modulate pathophysiological changes. Over the last decade, there have been great advancements in imaging instrumenta...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
Authors: Toussirot E, Bernard C, Bossert M Abstract PMID: 30873944 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
We present a series of patients with sarcoidosis associated PH and describe correlation between the pre-transplant hemodynamic data from a right heart catheterization (RHC) and vascular morphologic changes in the native explanted lungs.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 117 Source Type: research
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