The efficacy and safety of rufinamide in drug-resistant epilepsy: A meta-analysis of double-blind, randomized, placebo controlled trials

Epilepsy is one of the most common types of human neurological disorder, and 30% of patients with epilepsy continue to seizure, despite tailored medical therapy (drug-resistant epilepsy) (Bialer and White, 2010). Although surgical resection of the epileptic focus may abolish epileptic seizures, many individuals are poor surgical candidates because of multifocal seizure origin or the epileptic focus being near the eloquent cortex (Berg, 2011; Wiebe, 2014). Moreover, about one third of patients, who seem seizure free after surgical therapy will resume seizures in 3-5 years (Salanova et al., 2002; Tellez-Zenteno et al., 2005; Thom et al., 2010).
Source: Epilepsy Research - Category: Neurology Authors: Source Type: research