Targeting Tumors with Small Molecule Peptides.

Targeting Tumors with Small Molecule Peptides.
Curr Cancer Drug Targets. 2015 Nov 30;
Authors: Cheetham AG, Keith D, Zhang P, Lin R, Su H, Cui H
Abstract
Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites necessitates the use of targeting elements, of which there are a wide range in development. In this Review, we highlight recent examples of peptide-based targeting ligands that have been exploited to selectively deliver a chemotherapeutic payload to specific tumor-associated sites such as the vasculature, lymphatics, or cell surface. The advantages and limitations of such approaches will be discussed with a view to potential future development. Additionally, we will also examine how peptide-based ligands can be used diagnostically in the detection and characterization of cancers through their incorporation into imaging agents.
PMID: 26632435 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - November 30, 2015 Category: Cancer & Oncology Authors: Cheetham AG, Keith D, Zhang P, Lin R, Su H, Cui H Tags: Curr Cancer Drug Targets Source Type: research