miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

Conclusions
Our data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses. Thus, miR-10a could play a role in the pathogenesis and progression of IBD.

Source: Gut - October 8, 2015 Category: Gastroenterology Authors: Wu, W., He, C., Liu, C., Cao, A. T., Xue, X., Evans-Marin, H. L., Sun, M., Fang, L., Yao, S., Pinchuk, I. V., Powell, D. W., Liu, Z., Cong, Y. Tags: Inflammatory bowel disease Source Type: research