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Abatacept Might Be First-Ever Treatment for Rare Immune DeficiencyAbatacept Might Be First-Ever Treatment for Rare Immune Deficiency

Some devastating aspects of common variable immune deficiency are a result of a defect in trafficking of the immune down-regulator CTLA4, which can be overcome by treatment with abatacept. Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news

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AbstractSince the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, all...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
AbstractAnaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death. The use of validated clinical criteria can facilitate the diagnosis of anaphylaxis. Intramusc...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Research suggests that people with high IQ scores are more likely to have mood disorders, and a higher risk factor of ‘psychological overexcitabilities’ – perhaps that explains the behaviour of the man in the White HouseMy IQ is extremely, almost embarrassingly, high. I ’ve never actually taken an IQ test, mind you, but my educated guess is that, if I did, my score would be whatever is the highest possible. No doubt your IQ is lower than mine, but please don’t feel stupid or insecure because of this, it’s not your fault. You’re probably just born that way. And you know what? Thank ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Psychology Science Consciousness US news Donald Trump Artificial intelligence (AI) Computing Race issues World news Technology Social exclusion Society Economic policy Politics Source Type: news
Research suggests that people with high IQ scores are more likely to have mood disorders, and a higher risk factor of ‘psychological overexcitabilities’ – perhaps that explains the behaviour of the man in the White HouseMy IQ is extremely, almost embarrassingly, high. I ’ve never actually taken an IQ test, mind you, but my educated guess is that, if I did, my score would be whatever is the highest possible. No doubt your IQ is lower than mine, but please don’t feel stupid or insecure because of this, it’s not your fault. You’re probably just born that way. And you know what? Thank ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Psychology Science Consciousness US news Donald Trump Artificial intelligence (AI) Computing Race issues World news Technology Social exclusion Society Economic policy Politics Source Type: news
Authors: Ferguson BJ Abstract Preview Sinusitis is often easily recognized by the familiar complaints of paranasal pressure, tenderness, and headaches. What is more difficult is sorting out viral, bacterial, or fungal infection from allergy, anatomic obstruction, or underlying disease. Dr Ferguson outlines signs and symptoms that differentiate various forms of rhinosinusitis, discusses strengths and weaknesses of diagnostic measures, and summarizes appropriate therapeutic interventions. PMID: 29211638 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
This article reviews the latest recommendations and clinical practice guidelines for peanut allergies among the pediatric population. Recommendations in this paper were compiled using information collected from a variety of publications of accredited professional organizations. Peanut allergies are the body's response to what it sees to be an unwanted substance in the body. This article focuses on the causes, signs and symptoms, prevention, diagnosis, and management of peanut allergies.
Source: Journal of Pediatric Health Care - Category: Pediatrics Authors: Tags: Practice Guidelines Source Type: research
Early-onset atopic dermatitis (AD) related repression of the immune regulatory NLRP2 is driven by promoter hypermethylation starting already at time of birth providing an early opportunity to modulate innate immunity to potentially mitigate AD development.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionPatch testing is relevant as a screening tool in the management of children with atopic dermatitis as they may have unacknowledged contact allergies contributing to or maintaining their skin symptoms. Children with atopic dermatitis seem to be at greater risk of sensitization to certain allergens including metals and components of skin care products.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Conclusions The present results suggest that allergy is not directly involved in the clinical expression and specific inflammatory pathways of CRSwNP. New therapies target inflammation signaling pathways, and identifying accurate blood and tissue biomarkers will be the line of research most likely to improve treatment of CRSwNP.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
View Original Article Here: How Long Does Shingles Last In The Elderly? Shingles is a viral infection that follows a varicella-zoster infection, although it can take decades for symptoms of the secondary disease to emerge. The condition presents as a painful and blistering rash, but it is not life-threatening. According to the Center for Disease Control, there are nearly one million cases in the United States each year, and almost half of those cases are in older adults over age 60. Some people only see one instance of the illness, while others have recurring symptoms, but 30 percent of Americans will develop shingles at s...
Source: Shield My Senior - Category: Geriatrics Authors: Tags: Senior Safety Source Type: blogs
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