Structure of GTP-specific succinyl-CoA synthetase in complex with CoA

Pig GTP-specific succinyl-CoA synthetase is an αβ-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Å resolution. The structure shows CoA bound to the amino-terminal domain of the α-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.

Source: Acta Crystallographica Section F - July 29, 2015 Category: Biochemistry Authors: Huang, J.Malhi, M.Deneke, J.Fraser, M.E. Tags: ligase ATP-grasp fold research communications Source Type: research