Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity

Trends Biochem Sci. 2024 Apr 26:S0968-0004(24)00101-4. doi: 10.1016/j.tibs.2024.04.004. Online ahead of print.ABSTRACTA recently characterized RNA modification is NAD+-modified RNAs (NAD-RNAs). Various enzymes decap NAD-RNAs, and Wang and Yu et al. now describe another, namely Toll/interleukin-1 receptor (TIR) domain-containing proteins of bacteria and Archaea. TIR decapping products are a specific variant of cyclic ADP ribose (ADPR)-RNAs (v-cADPR-RNAs), opening a new window to the NAD-RNA world.PMID:38677919 | DOI:10.1016/j.tibs.2024.04.004

Source: Trends in Biochemical Sciences - April 27, 2024 Category: Biochemistry Authors: Dechang Cao Source Type: research