Quinazolines annelated at the N(3)-C(4) bond: Synthesis and biological activity

Eur J Med Chem. 2024 Apr 18;271:116411. doi: 10.1016/j.ejmech.2024.116411. Online ahead of print.ABSTRACTThis review covers article and patent data obtained mostly within the period 2013-2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)-C(4) bond in the perspective of drug development and discovery.PMID:38669910 | DOI:10.1016/j.ejmech.2024.116411

Source: European Journal of Medicinal Chemistry - April 26, 2024 Category: Chemistry Authors: Emiliya V Nosova Galina N Lipunova Yulia V Permyakova Valery N Charushin Source Type: research