Towards fair and clinically relevant polygenic predictions

Trends Genet. 2024 Apr 19:S0168-9525(24)00076-3. doi: 10.1016/j.tig.2024.04.002. Online ahead of print.ABSTRACTLennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models.PMID:38643035 | DOI:10.1016/j.tig.2024.04.002
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research