The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin

Damianov et  al. developed a method for the isolation of complexes derived from spliceosomes formed in vivo, applicable both in examining functions of spliceosomal factors and mapping of spliceosome assembly sites. They demonstrated that the splicing regulators RBM5 and RBM10 are U2 snRNP-associated factors r epressing exon inclusion following branch site selection.

Source: Molecular Cell - March 26, 2024 Category: Cytology Authors: Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L. Black Tags: Article Source Type: research