A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow

Chem Asian J. 2024 Apr 15:e202400269. doi: 10.1002/asia.202400269. Online ahead of print.ABSTRACTDescribed is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.PMID:38619083 | DOI:10.1002/asia.202400269

Source: Chemistry, an Asian Journal - April 15, 2024 Category: Chemistry Authors: Xin-Jie Lin Chien-Lung Wang Chi-How Peng Hsueh-Ju Liu Yen-Ku Wu Source Type: research