Calcified chondroid mesenchymal neoplasm: report of a case involving the temporomandibular joint region and review of the literature

Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 Jan 11:S2212-4403(24)00001-4. doi: 10.1016/j.oooo.2023.12.791. Online ahead of print.ABSTRACTThe calcified chondroid mesenchymal neoplasm (CCMN) represents a recently recognized tumor type with only 50 well-documented cases in the English-language literature. Herein we report an additional case of CCMN presenting as a large mass in the temporomandibular joint region of a 41-year-old female. A review of previously reported cases and the current case of CCMN shows the following features: 1) average age 52 years (range 14-87 years) and an approximately even sex distribution; 2) most frequently involved sites: distal extremities (including foot, hand, wrist, forearm) (n=41) and temporomandibular joint/temporal/parotid region (n=9); 3) multilobular soft tissue tumor with chondroid to cartilaginous matrix, often grungy or lace-like calcifications, and variable cytologic atypia; 4) frequently detected FN1 rearrangement (n=15), including FN1 fusion with FGFR2 (n=7) or other receptor tyrosine kinases; 5) 2 reported local recurrences (after incomplete excision); 6) no reports of malignant biologic behavior.PMID:38616481 | DOI:10.1016/j.oooo.2023.12.791
Source: Hand Surgery - Category: Surgery Authors: Source Type: research