An Autopsy Case of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Induced by Propylthiouracil

Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3397-23. Online ahead of print.ABSTRACTAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complication caused by antithyroid drugs, particularly propylthiouracil (PTU). Most patients experience organ failure due to the affects of the treatment regimen. We herein report the case of an 89-year-old woman whose severe AAV induced by PTU resulted in various instances of organ failure that eventually led to death after 9 years of PTU therapy. During autopsy, we identified five types of organ failure. As AAV is a potentially fatal disease, the development of various vasculitis symptoms during PTU therapy should therefore be carefully monitored.PMID:38599866 | DOI:10.2169/internalmedicine.3397-23

Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Genki Fujii Ryosuke Yoshihara Toshiki Hyodo Ikuhiro Ishida Ryoko Onishi Masayo Fujimoto Keiji Iida Source Type: research