Paradoxical Psoriasis: From Its Many Faces to Possible Shared Therapeutic Targets

Paradoxical psoriasis (PP) may be defined as the unexpected occurrence or worsening of psoriasiform skin lesions in patients undergoing treatment with biologics or small molecules (Murphy et  al, 2022). In this letter, we comment on the different settings of presentation of PP, including cases developing under anti–IL-4/IL-13 and anti–TNF-α agents, highlighting differences as well as shared pathophysiological features. An overview of available evidence is provided and put in persp ective, with possible implications for future research on druggable targets.

Source: Journal of Investigative Dermatology - March 19, 2024 Category: Dermatology Authors: Carlo Alberto Maronese, Antonio Costanzo, Michel Gilliet, Angelo Valerio Marzano Tags: Letters to the Editor Source Type: research