Biobank-scale inference of multi-individual identity by descent and gene conversion

We present a method for efficiently identifying clusters of identical-by-descent haplotypes in biobank-scale sequence data, and we demonstrate how these clusters can be used to identify alleles that have been changed by gene conversion. We apply our methods to UK Biobank sequence data.

Source: The American Journal of Human Genetics - March 20, 2024 Category: Genetics & Stem Cells Authors: Sharon R. Browning, Brian L. Browning Tags: Article Source Type: research