Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates

TetraHer is a new method for estimating the heritability of diseases that allows for ascertainment of cases and for contributions of covariates. Applied to UK Biobank data, TetraHer finds 107 ICD-10 codes with significant heritability.

Source: The American Journal of Human Genetics - March 14, 2024 Category: Genetics & Stem Cells Authors: Doug Speed, David M. Evans Tags: Article Source Type: research