The proteomic landscape of genotoxic stress-induced micronuclei

Using subcellular fractionation followed by mass spectrometry-based proteomics, MacDonald et  al. profile the protein landscape of genotoxic stress-induced micronuclei (MN), compared with nuclei and cytoplasm. Components of the mRNA spliceosome were consistently deficient in MN, and the authors demonstrate that this elicits pathogenic MN DNA fragmentation in transcribing MN.

Source: Molecular Cell - February 28, 2024 Category: Cytology Authors: Kate M. MacDonald, Shahbaz Khan, Brian Lin, Rose Hurren, Aaron D. Schimmer, Thomas Kislinger, Shane M. Harding Tags: Resource Source Type: research