A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

Bao et  al. reveal that the histone deacetylase complex MiDAC promotes H2AK5K9 deacetylation and licenses NHEJ synaptic complex assembly. In the context of MiDAC ablation, elevated H2AK5acK9ac serves as a docking signal for BRD4 to compartmentalize with KU around damaged chromatin, and this aberrant conde nsation inhibits DNA end synapsis and reduces genome stability.

Source: Molecular Cell - February 28, 2024 Category: Cytology Authors: Kaiwen Bao, Yanhui Ma, Yuan Li, Xilin Shen, Jiao Zhao, Shanshan Tian, Chunyong Zhang, Can Liang, Ziyan Zhao, Ying Yang, Kai Zhang, Na Yang, Fei-long Meng, Jihui Hao, Jie Yang, Tao Liu, Zhi Yao, Ding Ai, Lei Shi Tags: Article Source Type: research