42. Dysregulated Puberty in Panhypopituitarism

Panhypopituitarism among patients with optic nerve hypoplasia ranges from 6% to 82% (Oatman, McClellan, Olson,  et al., 2015). In keeping with hypothalamic-pituitary dysfunction, pubertal disturbances like hypogonadotropic hypogonadism are logically anticipated. Current limited estimates indicate that among patients with optic nerve hypoplasia and panhypopituitarism, 40% of females have normal pubertal d evelopment (menarche from age 10.5 to 13 years) (Oatman, McClellan, Olson, et al., 2015). In a case series of 101 children with optic nerve hypoplasia and panhypopituitarism, 50% of subjects had gonadotropin deficiency while 2% had precocious puberty (Oatman, McClellan, Olson, et al., 2015).
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research