Restricted Net Treatment Benefit in oncology

The restricted Net Treatment Benefit (rNTB) is a clinically meaningful and tractable estimand of the overall treatment effect assessed in randomized trials when at least one survival endpoint with time restriction is used. Its interpretation does not rely on parametric assumptions such as proportional hazards, can be estimated without bias even in presence of independent right-censoring and can include a pre-specified threshold of minimal clinically relevant difference.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Original Article Source Type: research