PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man

In conclusion, the PBTK model showed to be a promising tool to assess the dynamic interplay of enzyme induction and toxification pathways.PMID:38528153 | DOI:10.1007/s00204-024-03698-2

Source: Archives of Toxicology - March 26, 2024 Category: Toxicology Authors: Anja Lehmann Ina Geburek Stefanie Hessel-Pras Anne-Margarethe Enge Hans Mielke Christine M üller-Graf Charlotte Kloft Christoph Hethey Source Type: research