GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury

Acute lung injury (ALI) is a devastating clinical disease caused by different factors, with high morbidity and mortality. It has been shown that lung injury and inflammation caused by lipopolysaccharide (LPS) can be modulated by NLRP3 inflammasome activation, yet its exact function within the airway epithelium is still unknown. Meanwhile, glucose transporter protein 1 (GLUT1) has been shown to contribute to a number of inflammatory illnesses, including ALI. The present study was aimed to assess GLUT1's function in NLRP3 inflammasome activation of airway epithelium in LPS-induced acute lung injury.

Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Jiehong Li, Yijian Li, Guanjin Chen, Yan Liang, Jianpeng Xie, Shuiying Zhang, Kai Zhong, Tong Jiang, Haisu Yi, Haixiong Tang, Xin Chen Tags: Regular Article Source Type: research