Spatial mass cytometry-based single cell imaging reveals a disrupted epithelial-immune axis in prurigo nodularis
Prurigo nodularis (PN) is a chronic, inflammatory skin condition that disproportionately affects African Americans and features intensely pruritic, hyperkeratotic nodules on the extremities and trunk. PN is understudied compared to other inflammatory skin diseases, with the spatial organization of the cutaneous infiltrate in PN yet to be characterized. In this work, we employ spatial imaging mass cytometry to visualize prurigo nodularis lesional skin inflammation and architecture with single cell resolution through an unbiased machine learning approach.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Jay Patel, Junwen Deng, Anusha Kambala, Kevin K. Lee, Hannah L. Cornman, Varsha Parthasarathy, Thomas Pritchard, Shihua Chen, Alexei G. Hernandez, Sarah Shin, Olusola O. Oladipo, Madan M. Kwatra, Won Jin Ho, Shawn G. Kwatra Tags: Original Article Source Type: research