Structural atlas of human primary microRNAs generated by SHAPE-MaP

Despite a crucial role in miRNA maturation, structural features of pri-miRNAs remain largely unclear. Using SHAPE-MaP, Baek et  al. determined highly reliable secondary structures of 476 human pri-miRNAs. Combined with processing data, the resource annotates the determinants of pri-miRNA processing with high accuracy and enables the designing of more potent shRNAs.

Source: Molecular Cell - March 5, 2024 Category: Cytology Authors: S. Chan Baek, Boseon Kim, Harim Jang, Kijun Kim, Il-Soo Park, Dal-Hee Min, V. Narry Kim Tags: Resource Source Type: research