Sister chromatid cohesion halts DNA loop expansion

The cohesin ring has long been known for its role in mediating sister chromatids cohesion (SCC) in eukaryotes during G2/M. Basti é et al. demonstrate that these cohesins involved in SCC represent roadblocks to the extrusion of the chromatin loops that organize chromosomes at that stage in eukaryotes.

Source: Molecular Cell - March 6, 2024 Category: Cytology Authors: Nathalie Basti é, Christophe Chapard, Axel Cournac, Sanae Nejmi, Henri Mboumba, Olivier Gadal, Agnès Thierry, Frederic Beckouët, Romain Koszul Tags: Short article Source Type: research