Assay Validation of Cell-Free DNA Shallow Whole-Genome Sequencing to Determine Tumor Fraction in Advanced Cancers

We describe assay validation of this approach to facilitate broad clinical application, including evaluation of assay sensitivity, precision, repeatability, reproducibility, pre-analytic factors, and DNA quality/quantity.

Source: Journal of Molecular Diagnostics - March 13, 2024 Category: Pathology Authors: Micah Rickles-Young, Gabriel Tinoco, Junko Tsuji, Sam Pollock, Marcy Haynam, Heather Lefebvre, Kristyn Glover, Dwight H. Owen, Katharine A. Collier, Gavin Ha, Viktor A. Adalsteinsson, Carrie Cibulskis, Niall J. Lennon, Daniel G. Stover Tags: Regular article Source Type: research