Architecture of an RNA polymerase ribozyme illuminates the RNA World

Trends Genet. 2024 Mar 13:S0168-9525(24)00049-0. doi: 10.1016/j.tig.2024.02.008. Online ahead of print.ABSTRACT'Ribo-organisms' of the primordial RNA World would have needed ribozymes that catalyze RNA replication. McRae, Wan, Kristoffersen et al. recently revealed how these RNA replicases might have functioned by solving the structure of an artificial polymerase ribozyme. This work illustrates how complex RNA structures evolve, with implications for the origins of life.PMID:38485607 | DOI:10.1016/j.tig.2024.02.008

Source: Trends in Genetics : TIG - March 14, 2024 Category: Genetics & Stem Cells Authors: David M Shechner Source Type: research