Ficolin-A/2 Aggravated Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D –Induced Pyroptosis

This study investigated whether ficolin-A influences NET formation through pyroptosis to exacerbate lipopolysaccharide (LPS)-induced lung injury. The expression of ficolin-A/2, NETs, and pyroptosis-related molecules was investigated in animal and cell models. Knockout and knockdown (recombinant protein) methods were used to elucidate regulatory mechanisms. The Pearson correlation coefficient was used to analyze the correlation between ficolins and pyroptosis- and NET-related markers in clinical samples.

Source: American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Li Huang, Xiaowu Tan, Weixia Xuan, Qing Luo, Li Xie, Yunzhu Xi, Rong Li, Li Li, Feifan Li, Meiyun Zhao, Yongliang Jiang, Xu Wu Tags: Regular article Source Type: research