Automated radiosynthesis of [ < sup > 18 < /sup > F]DPA-714 on a commercially available IBA Synthera ®

Appl Radiat Isot. 2024 Mar 5;207:111257. doi: 10.1016/j.apradiso.2024.111257. Online ahead of print.ABSTRACTThe goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [18F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO3 as the phase transfer agent in place of Kryptofix® 222 in a 65-min synthesis with an average activity yield of 24.6 ± 3.8% (n = 5). Successful quality control testing and process validation results are reported.PMID:38461627 | DOI:10.1016/j.apradiso.2024.111257

Source: Applied Radiation and Isotopes - March 10, 2024 Category: Radiology Authors: Amy L V āvere Arijit Ghosh Victor Amador Diaz Allison J Clay Peter M Hall Kiel D Neumann Source Type: research