Structure modification of anoplin for fighting resistant bacteria

Eur J Med Chem. 2024 Feb 24;268:116276. doi: 10.1016/j.ejmech.2024.116276. Online ahead of print.ABSTRACTThe emergence of bacterial resistance has posed a significant challenge to clinical antimicrobial treatment, rendering commonly used antibiotics ineffective. The development of novel antimicrobial agents and strategies is imperative for the treatment of resistant bacterial infections. Antimicrobial peptides (AMPs) are considered a promising class of antimicrobial agents due to their low propensity for resistance and broad-spectrum activity. Anoplin is a small linear α-helical natural antimicrobial peptide that was isolated from the venom of the solitary wasp Anplius samariensis. It exhibits rich biological activity, particularly broad-spectrum antimicrobial activity and low hemolytic activity. Over the past three decades, more than 40 research publications on anoplin have been made available online. This review focuses on the advancements of anoplin in antimicrobial research, encompassing its sources, characterization, antimicrobial activity, influencing factors and structural modifications. The aim is to provide assistances for the development of new antimicrobial agents that can combat bacterial resistance.PMID:38452726 | DOI:10.1016/j.ejmech.2024.116276

Source: European Journal of Medicinal Chemistry - March 7, 2024 Category: Chemistry Authors: Chao Zhong Jing Zou Wenbo Mao Ping Yang Jingying Zhang Sanhu Gou Yun Zhang Hui Liu Jingman Ni Source Type: research