Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3

AbstractIndoline-5-sulfonamide derivatives of benzocaine have been synthesized using a sequence of three reactions:N-acylation, sulfochlorination, sulfonamidation, and their antienteroviral activity has been evaluated. Two compounds, namely, ethyl 4-((1-(cyclobutanecarbonyl)indoline)-5-sulfonamido)benzoate and ethyl 4-((1-benzoylindoline)-5-sulfonamido)benzoate exhibited a medium level of activity against coxsackievirus B3 (Nancy strain) in vitro. Their antiviral potential is exerted upon prophylactic application when added to cell culture before infection with the virus.

Source: Medicinal Chemistry Research - March 1, 2024 Category: Chemistry Source Type: research