The efficacy of the levonorgestrel intrauterine system versus oral megestrol acetate in treating atypical endometrial hyperplasia: a superior randomized controlled trial

CONCLUSION: Compared to MA, the LNG-IUS was more efficacious in treating AEH in women who declined hysterectomy, especially those with moderate/severe obesity, with fewer adverse effects and less weight gain. Extending therapy to 12 months for persistent cases would improve regression rates with reasonable safety. Alternate hysteroscopic and office sampling seemed convenient for follow-up.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04385667.PMID:38425141 | DOI:10.3802/jgo.2024.35.e62
Source: Journal of Gynecologic Oncology - Category: OBGYN Authors: Source Type: research