MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling

CONCLUSIONS: These results suggest that blockade of miR-1225-5p prevents lens fibrosis via targeting Keap1 thereby inhibiting Nrf2 activation. The 'miR-1225-Keap1-Nrf2' signaling axis presumably holds therapeutic promise in the treatment of fibrotic cataracts.PMID:38450708 | DOI:10.1080/02713683.2024.2316712

Source: Current Eye Research - March 7, 2024 Category: Opthalmology Authors: Peihong Wang Lixiong Gao Tianju Ma Zi Ye Zhaohui Li Source Type: research