COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells

Coenzyme Q, a redox lipid crucial for cellular bioenergetics and homeostasis, is synthesized by a multi-step pathway. Here, Pelosi et  al. unveil the missing enzyme of the eukaryotic pathway by showing that COQ4 functions as an oxidative decarboxylase on the carbon 1 of coenzyme Q intermediates.

Source: Molecular Cell - January 30, 2024 Category: Cytology Authors: Ludovic Pelosi, Laura Morbiato, Arthur Burgardt, Fiorella Tonello, Abigail K. Bartlett, Rachel M. Guerra, Katayoun Kazemzadeh Ferizhendi, Maria Andrea Desbats, B érengère Rascalou, Marco Marchi, Luis Vázquez-Fonseca, Caterina Agosto, Giuseppe Zanotti, Tags: Short article Source Type: research