Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91

Extracellular succinate is an auto- and paracrine metabolic stress signal sensed by SUCNR1. Using MD simulations, Shenol et  al. found that SUCNR1 has two low-energy binding sites, and its selective activation by high, local concentrations of succinate requires simultaneous occupancy of both high-affinity sites.

Source: Molecular Cell - February 6, 2024 Category: Cytology Authors: Aslihan Shenol, Michael L ückmann, Mette Trauelsen, Matteo Lambrughi, Matteo Tiberti, Elena Papaleo, Thomas M. Frimurer, Thue W. Schwartz Tags: Article Source Type: research