Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils

The eukaryotic SMC complexes cohesin, condensin, and the Smc5/6 complex are DNA-loop-extruding motors. Jeppsson et  al. show that Smc5/6 preferentially initiates loop extrusion on overtwisted, also called positively supercoiled, DNA. In cells, Smc5/6 is found at sites with transcription-induced positive supercoils, where it controls the spatial organization of chromosomes.

Source: Molecular Cell - January 30, 2024 Category: Cytology Authors: Kristian Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide Giorgio Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, Camilla Bj örkegren Tags: Article Source Type: research