Meropenem extraction by ex vivo extracorporeal life support circuits

CONCLUSION: Meropenem is rapidly cleared by hemodiafiltration during CRRT. There is minimal adsorption of meropenem to ECMO circuit components; however, meropenem undergoes significant degradation and/or plasma metabolism at physiological conditions. These ex vivo findings will advise pharmacists and physicians on the appropriate dosing of meropenem.PMID:38099629 | PMC:PMC10723574 | DOI:10.1051/ject/2023035
Source: Journal of Extra-Corporeal Technology - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research