Expression and function of VISTA on myeloid cells

Biochem Pharmacol. 2024 Feb 28:116100. doi: 10.1016/j.bcp.2024.116100. Online ahead of print.ABSTRACTV-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, including neutrophils, monocytes, macrophages, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs). In addition, we will discuss whether the functions of VISTA on these cells impact the disease processing.PMID:38428824 | DOI:10.1016/j.bcp.2024.116100

Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Siyu Li Geng Wang Yan Ren Xinyue Liu Yixuan Wang Jianing Li Hua Liu Jiaqiang Yang Jingjun Xing Yanru Zhang Canxia He Suling Xu Xin Hou Na Li Source Type: research