Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference

by Luz Mar ía López Ruiz, Dominic Johnson, William H. Gittens, George G. B. Brown, Rachal M. Allison, Matthew J. Neale During meiosis, genetic recombination is initiated by the formation of many DNA double-strand breaks (DSBs) catalysed by the evolutionarily conserved topoisomerase-like enzyme, Spo11, in preferred genomic sites known as hotspots. DSB formation activates the Tel1/ATM DNA damage responsive (DDR) kinase, locally inhibiting Spo11 activity in adjacent hotspots via a process known as DSB interference. Intriguingly, inS.cerevisiae, over short genomic distances (

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011140

Source: PLoS Genetics - March 1, 2024 Category: Genetics & Stem Cells Authors: Luz Mar ía López Ruiz Source Type: research

More News: Genetics