Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis

p21 (CdC42/RAC1)-activated kinases are implicated in the nodal point of several oncogenic signaling pathways. Indeed, the aberrant overexpression or mutational activation of p21 (CdC42/RAC1)-activated kinase isoforms is frequently observed in numerous human tumors. Recent reports suggest that the enhanced p21 (CdC42/RAC1)-activated kinase activity is a hallmark of many oncogenic cellular processes (Radu et  al, 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research