Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis
p21 (CdC42/RAC1)-activated kinases are implicated in the nodal point of several oncogenic signaling pathways. Indeed, the aberrant overexpression or mutational activation of p21 (CdC42/RAC1)-activated kinase isoforms is frequently observed in numerous human tumors. Recent reports suggest that the enhanced p21 (CdC42/RAC1)-activated kinase activity is a hallmark of many oncogenic cellular processes (Radu et al, 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Kimi Araki, Yuichi Wakabayashi Tags: Letters to the Editor Source Type: research