Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production

How cells induce the production of antiviral molecules while shutting down protein translation to limit viral replication remains unclear. Here, Harioudh et  al. show a non-canonical function for the interferon-induced antiviral protein, OAS1, which sequesters and protects Ifnb mRNA from degradation to sustain innate antiviral protection against West Nile virus.

Source: Immunity - February 28, 2024 Category: Allergy & Immunology Authors: Munesh K. Harioudh, Joseph Perez, Zhenlu Chong, Sharmila Nair, Lomon So, Kevin D. McCormick, Arundhati Ghosh, Lulu Shao, Rashmi Srivastava, Frank Soveg, Thomas S. Ebert, Maninjay K. Atianand, Veit Hornung, Ram Savan, Michael S. Diamond, Saumendra N. Sarka Tags: Article Source Type: research