The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy

Autophagy. 2024 Feb 27. doi: 10.1080/15548627.2024.2323259. Online ahead of print.ABSTRACTProteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroautophagy/autophagy and chaperoning of nascent proteins. Here, we explore the crosstalk between autophagy and the HSP90 chaperone in maintaining proteostasis, highlighting their interplay and significance in cellular homeostasis.PMID:38411135 | DOI:10.1080/15548627.2024.2323259

Source: Autophagy - February 27, 2024 Category: Cytology Authors: Sarah J Backe Jennifer A Heritz Mehdi Mollapour Source Type: research