Mineralized collagen scaffolds for regenerative engineering applications

Curr Opin Biotechnol. 2024 Feb 24;86:103080. doi: 10.1016/j.copbio.2024.103080. Online ahead of print.ABSTRACTCollagen is a primary constituent of the tissue extracellular matrix. As a result, collagen has been a common component of tissue engineering biomaterials, including those to promote bone regeneration or to investigate cell-material interactions in the context of bone homeostasis or disease. This review summarizes key considerations regarding current state-of-the-art design and use of collagen biomaterials for these applications. We also describe strategic opportunities for collagen biomaterials to address a new era of challenges, including immunomodulation and appropriate consideration of sex and other patient characteristics in biomaterial design.PMID:38402689 | DOI:10.1016/j.copbio.2024.103080

Source: Current Opinion in Biotechnology - February 25, 2024 Category: Biotechnology Authors: Vasiliki Kolliopoulos Brendan Ac Harley Source Type: research