The tumor niche can reprogram long-lived protumorigenic neutrophils

Trends Immunol. 2024 Feb 22:S1471-4906(24)00026-7. doi: 10.1016/j.it.2024.02.001. Online ahead of print.ABSTRACTThe heterogeneity and plasticity of neutrophils in tumor-host interactions and how tumor signals induce reprogramming of neutrophil subpopulations need further investigation. Ng et al. recently reported that a hypoxic-glycolytic niche in mouse tumors could reprogram mature and immature neutrophils into a long-lived and terminally-differentiated subset, which promoted angiogenesis and tumor growth.PMID:38395739 | DOI:10.1016/j.it.2024.02.001
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research