Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples

Nature Protocols, Published online: 23 February 2024; doi:10.1038/s41596-024-00962-8Phylogenetic trees from whole-genome sequencing datasets with the pipeline Sequoia are reconstructed to define the evolutionary history of clonally expanding cells and to clarify how somatic mutations shape normal cell behavior.

Source: Nature Protocols - February 23, 2024 Category: Biomedical Science Authors: Tim H. H. Coorens Michael Spencer Chapman Nicholas Williams Inigo Martincorena Michael R. Stratton Jyoti Nangalia Peter J. Campbell Source Type: research