Immunosuppressive CD29+ Treg accumulation in the liver in mice on checkpoint inhibitor therapy

Conclusion
We propose that CD29+ Tregs constitute a unique subpopulation of hepatic Tregs that are primed to respond to ICI agents and mediate resistance.

Source: Gut - February 23, 2024 Category: Gastroenterology Authors: Green, B. L., Myojin, Y., Ma, C., Ruf, B., Ma, L., Zhang, Q., Rosato, U., Qi, J., Revsine, M., Wabitsch, S., Bauer, K., Benmebarek, M.-R., McCallen, J., Nur, A., Wang, X., Sehra, V., Gupta, R., Claassen, M., Wang, X. W., Korangy, F., Greten, T. F. Tags: Gut Hepatology Source Type: research