The Mark Coventry Award: PhotothermAA Gel Combined with Debridement, Antibiotics, and Implant Retention (DAIR) Significantly Decreases Implant Biofilm Burden and Soft-Tissue Infection in a Rabbit Model of Knee Periprosthetic Joint Infection

Chronic periprosthetic joint infection (PJI) is a major complication of total joint arthroplasty. The underlying pathogenesis often involves the formation of bacterial biofilm that protects the pathogen from both host immune responses and antibiotics. The gold standard treatment requires implant removal, a procedure that carries associated morbidity and mortality risks. Strategies to preserve the implant while treating PJI are desperately needed. Our group has developed an anti-biofilm treatment, PhotothermAA gel, that has shown complete eradication of two-week-old mature biofilm in vitro.

Source: The Journal of Arthroplasty - February 22, 2024 Category: Orthopaedics Authors: Carlos A. Higuera-Rueda, Nicolas S. Piuzzi, Nathalie B. Milbrandt, Yu Hsin Tsai, Alison K. Klika, Anna Cristina S. Samia, Anabelle Visperas Tags: 2024 Knee Society Award Source Type: research